Molecular characterization of three new virulent Newcastle disease virus variants isolated in China.

نویسندگان

  • Lei-Tao Tan
  • Huai-Ying Xu
  • You-Ling Wang
  • Zhuo-Ming Qin
  • Lei Sun
  • Wen-Jun Liu
  • Zhi-Zhong Cui
چکیده

Three cases of Newcastle disease virus (NDV) found in nature had the lentogenic motif (112)G-R-Q-G-R-L(117) in their fusion protein cleavage sites. However, both intracerebral pathogenicity and intravenous pathogenicity indexes showed that these NDV isolates were virulent. In comparison with the LaSota live virus vaccine, these viruses had significant genetic variations in the hemagglutinin-neuraminidase gene.

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عنوان ژورنال:
  • Journal of clinical microbiology

دوره 46 2  شماره 

صفحات  -

تاریخ انتشار 2008